NADH Powder

NADH Powder (≥98% HPLC) | B2B Pharmaceutical Grade Supplier 

Earth Made Nutritions Inc. supplies NADH Powder (Reduced β-Nicotinamide Adenine Dinucleotide)with verified ≥98.0% purity via HPLC analysis. As a California-based ingredient supplier operating since 2018, we specialize in coenzyme raw materials for the nutraceutical and functional food industries.

Key Supply Capabilities:

· Minimum Order: 25kg per aluminum drum

· Standard Lead Time: 2 business days for stock items (US warehouses)

· Certifications: NSF GMP, Kosher, Halal, ISO 9001, FSSC 22000

· Stability: ≤3.0% moisture content (Karl Fischer method)

Our inventory network across four US distribution centers supports just-in-time manufacturing schedules for dietary supplement brands, contract manufacturers, and formulators.

Product Specifications

Applications in Dietary Supplements

Energy & Mitochondrial Support Formulas

NADH serves as an electron donor in the mitochondrial electron transport chain. Formulators target this ingredient for products positioned around:

· Cellular energy metabolism

· Age-related vitality support

· Physical performance and recovery

Formulation Considerations:

Enteric coating is essential due to gastric acid sensitivity. Our powder's particle size distribution (D50: 80-120 μm) facilitates uniform coating adhesion during pelletization.

Cognitive Function Products

The reduced coenzyme participates in dopamine synthesis pathways. Sublingual delivery formats bypass digestive degradation:

· Fast-dissolve tablets

· Sublingual strips

· Liquid concentrates

Taste Profile:Neutral to slightly bitter. Masking agents (e.g., natural flavors) recommended for consumer acceptability.

Sports Nutrition Complexes

When combined with CoQ10, electrolytes, and B-vitamins, NADH supports energy conversion during exercise. However, direct mixing with acidic ingredients (ascorbic acid, citric acid) accelerates degradation.

Solutions:

· Dual-chamber capsules

· Microencapsulation with enteric polymers

· Separate sachets in multi-component systems

Quality Control & Manufacturing

Analytical Methods

Purity Verification

HPLC analysis with UV detection at 340nm quantifies NADH content and distinguishes it from the oxidized NAD⁺ form. Each production lot includes chromatographic fingerprinting for consistency verification.

Stability Testing

Karl Fischer titration confirms moisture levels below 3.0% - a critical threshold for oxidation prevention. Batches exceeding this parameter are rejected before packaging.

Contaminant Screening

· Heavy metals: ICP-MS per USP <233>

· Microbial testing: USP <2021> and <2022>

· Residual solvents: GC-FID per ICH Q3C guidelines

Production Method

We utilize enzymatic biocatalysis rather than yeast extraction. This method produces the stereospecific β-anomer with minimal impurities, resulting in superior stability profiles compared to fermentation-derived material.

Process Advantages:

· Higher stereochemical purity

· Lower endotoxin levels

· Reduced batch-to-batch variation

· Better compatibility with enteric coating systems

Formulation Stability Guidelines

pH Sensitivity

NADH degrades rapidly below pH 7.0. Avoid direct contact with:

· Vitamin C (ascorbic acid)

· Alpha lipoic acid

· Citric acid buffers

Light & Oxygen Protection

Yellow coloration indicates intact reduced form. Brown discoloration signals oxidation to NAD⁺.

Packaging Recommendations:

· Amber or opaque bottles

· Blister packs with aluminum backing

· Nitrogen flushing for powder blends

Moisture Control

Water activity above 0.30 accelerates hydrolysis of NADH Powder. Use desiccants (silica gel) in finished product packaging.

Certifications & Compliance

Earth Made Nutritions Inc. maintains third-party verified quality systems:

· NSF GMP Registration:Dietary supplement ingredient manufacturing

· Kosher Certification:Orthodox Union (OU)

· Halal Certification:Islamic Food and Nutrition Council of America (IFANCA)

· ISO 9001:2015:Quality management system

· FSSC 22000:Food safety management

Documentation provided with each shipment:

· Certificate of Analysis (CoA) with test results

· Material Safety Data Sheet (MSDS/SDS)

· Allergen Declaration Statement

· GMO-Free Statement

· BSE/TSE Free Certificate

Supply Chain & Logistics

Warehouse Locations

Stock inventory maintained at four US facilities:

· West Coast: California

· Southwest: Texas

· Midwest: Illinois

· East Coast: New Jersey

This distribution network enables 1-2 day ground shipping to major manufacturing hubs.

Order Processing

· Stock Items:Ship within 2 business days

· Custom Specifications:4-6 week lead time depending on requirements

· Sample Requests:Complimentary 100g samples available for qualified R&D projects

Minimum Order Quantities

· Standard Grade (≥98%):25kg per order

· Custom Particle Size:100kg minimum

· Microencapsulated Forms:Contact for MOQ

FAQ

Q: What is the NADH quality check upon receipt?

A: Initial screening is visual. Yellow powder indicates normal storage, whereas white powder shows NAD⁺ oxidation. To verify quantitatively, request CoA with HPLC chromatogram indicating 340nm absorption peak and NAD⁺ level < 1%.

Q: Which causes the product to brown?

A: Humidity causes oxidative deterioration. Brown represents advanced oxidation and potency loss. Dry storage at -20°C avoids this.

Q: Is NADH suitable for gummies?

A: Unadvisable. High water activity (Aw >0.60) and acidic pH degrade gummy matrices quickly. Try tablets or microencapsulated forms.

Q: What's the formulation difference between NADH and NAD⁺?

A: NAD⁺ is the oxidised form, while NADH is the reduced form with high-energy electrons. Because to handling difficulty, NADH costs 30-40% more and requires stricter stability controls (cold storage, light protection).

Q: Do you provide regulatory support documentation?

A: Yes. We supply all documentation required for NDI notifications, GRAS assessments, and international registrations including:

· Manufacturing process flowcharts

· Stability study data

· Safety literature reviews

· Specification sheets in multiple languages

Q: What production capacity do you maintain?

A: Current capacity supports 5,000kg monthly production. Lead times for stock items remain at 2 business days. Custom orders require 4-6 weeks depending on specifications.

Q: Can you match competitor specifications?

A: We evaluate competitor CoAs and can often match or exceed specifications. Provide the target CoA when requesting a quote, and our technical team will assess feasibility within 48 hours.

Contact Us

Do you have more questions about NADH Powder?

Email: info@em-herb.com