Caffeine Anhydrous 99%

Caffeine Anhydrous 99% Bulk Supplier | Pharmaceutical-Grade Quality 

North American companies buy Caffeine Anhydrous 99% (CAS 58-08-2) from Earth Made Nutritions Inc., which is used in medicine. Under NSF GMP and FSSC22000 standards, our California plant makes 99%+ pure white crystalline powder.

Specifications that stand out:

• Purity that meets USP/EP/BP standards: 98.5% to 102.0 % (anhydrous base).
• Not more than 0.5% moisture
• 90% pass 150 µm (100-mesh) in size.
• Four locations in the U.S. offer two-day stock processing.
• You can get free technical samples with a 25 kg minimum order quantity.

Product Specifications

Product Overview

What Is Caffeine Anhydrous 99%?

Some caffeine (1,3,7-Trimethylxanthine) is dehydrated and has less than 0.5% water in it. This is called Caffeine Anhydrous 99%. This drug made for pharmacology gives you:

Accurate dosing: 99% accuracy gets rid of recipe differences

This mix is very stable because it doesn't clump when there isn't enough wetness.

It is absorbed faster because it doesn't need to be broken down like natural products or caffeine citrate do.

Compact forms are more powerful per gram than plant-based sources like guarana and kola nuts.

The formula for an atom is C₈H₁N₄O₂.

Manufacturing Process

Source & Extraction

Our Caffeine Anhydrous comes from natural coffee beans and is taken out by:

1. Solvent extraction: ethyl acetate that is safe for food under GMP settings

2. Multistage crystallization: Gets rid of flaws to make it 99% pure or higher

3. Recrystallization: Gets rid of any leftover solvents (meets ICH Q3C limits)

4. Dried and milled: controlled particle size range for best flow

Quality Control

Every batch undergoes:

· HPLC purity analysis

· Karl Fischer moisture testing

· Laser diffraction particle sizing

· Heavy metals & microbiology screening

· Residual solvent analysis (GC-MS)

Certifications: NSF GMP Registered, FSSC22000, Kosher (OU), Halal, ISO 9001:2015

Applications & Formulation Benefits

Sports Nutrition

Pre-workout powders & energy supplements

· Fast-acting stimulant: Peak plasma levels in 45-60 minutes

· Synergy with beta-alanine, citrulline, and B-vitamins

· Low hygroscopicity prevents caking in powder blends

Fat burners & thermogenics

· Precise dosing for 100-300mg servings

· Stable in combination with green tea extract or capsaicin

· 24-month shelf life in HDPE bottles

Pharmaceutical

OTC pain relief (combination products)

· Adjuvant to acetaminophen/aspirin (enhances analgesic effect)

· Small API footprint: reduces tablet size vs. caffeine citrate

· Compatible with direct compression & wet granulation

Alertness & migraine relief

· Single-ingredient caffeine tablets (100-200mg)

· Stable in blister packaging (PVC/Alu)

Functional Beverages

Energy shots & RTD drinks

· Clean dissolution in acidic matrices (pH 2.5-4.0)

· No impact on flavor profile (vs. guarana extract)

· Heat-stable during pasteurization (up to 90°C)

Cosmetics

Eye creams & anti-fatigue serums

· Micronized grade available (D90 <10μm for smooth texture)

· Topical vasoconstrictor for reducing puffiness

Quality Documentation

We provide with each order:

· Certificate of Analysis (CoA)

· Material Safety Data Sheet (SDS)

· Allergen statement

· BSE/TSE declaration

· GMO-free statement

· Country of origin certificate

· Kosher/Halal certificates (upon request)

Why Choose Earth Made Nutritions?

✅ Reliable U.S. Supply Chain

· 4 regional warehouses: West Coast (CA), Midwest (IL), East Coast (NJ), South (TX)

· 2-day order processing: In-stock items ship within 48 hours

· Flexible packaging: 25kg fiber drums (food-grade PE liner) or custom sizes

✅ Technical Support

Our applications team assists with:

· Formulation optimization (stability testing recommendations)

· Regulatory documentation (allergen statements, BSE/TSE, GMO status)

· Custom particle sizing for specialized delivery systems

✅ Consistent Quality Since 2018

Assay consistency: <2% variance across lots.

Fully traceable from raw materials to completed products.

Expand to observant consumer markets with Kosher & Halal certification.

Particle Size Options

Standard Grade (100-mesh)

· Distribution: D10=50μm, D50=120μm, D90=180μm

· Applications: Tablets, capsules, powder blends

· Flow properties: Excellent for automatic encapsulation

Fine Grade (200-mesh)

· Distribution: D50=75μm, D90=120μm

· Applications: Beverage powders, fast-dissolve formats

Micronized Grade (Custom)

· Distribution: D90 <10μm

· Applications: Topical creams, nano-emulsions

· MOQ: 100kg | Lead time: 3-4 weeks

FAQ

Q: What's the difference between Caffeine Anhydrous and Caffeine Monohydrate?

Anhydrous contains <0.5% water vs. 8.5% in monohydrate. This means:

· 8% more active ingredient per gram

· Better stability in moisture-sensitive formulations

· No water activity contribution to powder blends

Q: Is your product natural or synthetic?

A: Our caffeine comes from coffee beans and is refined to pharmaceutical standards. It's chemically equivalent to synthetic caffeine but made from botanicals (most countries allow "naturally sourced" claims).

Q: Do you provide lower R&D quantities?

A: Yes. Free 100g formulation testing samples are available. Request custom quotes for 5-20kg pilot batches from our sales team.

Q: What's your typical lead time for custom particle sizing?

A: Standard micronization (D90 <10μm): 3-4 weeks post-order confirmation. Extra costs apply to rush orders.

Q: Do you certify organically?

A: Due to extraction, our Caffeine Anhydrous is not organic. We can recommend organic-certified caffeine suppliers.

Q: How do I qualify for Net 30 payment terms?

A: New customers pay upfront or COD. We provide Net 30 credit after 3 successful orders (subject to credit clearance).

Request Your Free Sample

Do you have more questions about Caffeine Anhydrous 99%?

Contact us:info@em-herb.com