Direct from California | Ships in 48 Hours | NSF GMP Certified
Ever since 2018, Earth Made Nutritions has supplied pharmaceutical-grade D-Mannose 99% to top North American supplement manufacturers. What distinguishes us:
✓Enzymatic conversion process- No harsh chemical solvents
✓4 U.S. warehouses- 48-hour delivery to your facility
✓Batch consistency- ±0.2% purity variance across lots
✓Full traceability- From non-GMO corn to your loading dock

| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder |
| Purity | 99% (HPLC verified) |
| CAS Number | 3458-28-4 |
| Molecular Formula | C6H12O6 |
| Molecular Weight | 180.16 g/mol |
| Melting Point | 126°C - 134°C |
| Solubility | 2480 g/L at 25°C |
| Package | 25kgs/drum |
| MOQ | 25kgs |
| Lead Time | In stock, 2nd day picking up |
| Sample | Free sample available |
D-Mannose is a simple sugar that your body doesn't metabolize like glucose. Instead:
1. 90% passes unchangedthrough the digestive system
2. Reaches the urinary tractin its active form
3. Near-zero glycemic impact- safe for diabetic formulations
This unique metabolic pathway makes it ideal for urinary health supplements, functional beverages, and diabetic-friendly products.
Our99% specificationmeans:
· No glucose contamination that competes with the active mechanism
· No hydrolysis by-products affecting taste
· No residual solvents triggering label warnings
Lower-purity alternatives (95-97%) often contain glucose or processing residues that dilute efficacy and complicate your Supplement Facts panel.
Every batch includes:
· HPLC purity confirmation
· Heavy metal screening (Pb, As, Cd, Hg)
· Microbial testing (E. coli, Salmonella: Negative)
· Specific rotation: +28.3° to +29.3° (confirms D-isomer)
�� NSF GMP | FSSC22000 | ISO 9001
�� Kosher | Halal | Organic (available)
Allergen status:Free from the 9 major allergens. Residual protein testing confirms <5 ppm.

1.Urinary Tract Supplements(65% of our customers)
Typical formula:
500-2000mg D-Mannose per serving
Additionally, cranberry extract (36% PACs) and Lactobacillus rhamnosus are often used.
Capsule, tablet, or powder form.
Case snapshot: A mid-sized company switched to our 99% purity grade from a 96% competition and had 23% more recurring purchases.
2.Functional Beverages
· Can withstand acidic pH (pH 2.8)
• Provides moderate sweetness (50-60% sugar) without calories.
· Instantly dissolves in cold water.
Wellness shots, cranberry juice blends, electrolytes are popular.
3.Pet Nutrition
Demand for cat and dog bladder supplements formulated with D-Mannose 99% is rising, and its natural sweetness increases the palatability of otherwise difficult recipes.
4.Diabetic-Friendly Products
Glycemic index ≈0. Supports urinary function without diabetes.

✅25kg minimum order- accessible for emerging brands
✅Bulk pricingavailable at 500kg, 1000kg, 2500kg tiers
✅Free samplesfor qualified formulators (ships in 24 hours)
· West Coast:Los Angeles, CA
· Southwest:Phoenix, AZ
· Midwest:Chicago, IL
· East Coast:Newark, NJ
Result:Most customers receive orders within 3-5 business days via standard freight.
· Standard: 25kg fiber drum with dual PE liner
· Custom packaging available for OEM partners
· All materials meet FDA food-contact requirements


Q: Does corn-versus-birch-derived matter?
A: Both produce identical CAS 3458-28-4 molecules. Enzymatic corn processing is more consistent and environmentally friendly than birch hydrolysis. Same specification.
Q: How to prevent powder blend clumping?
A: Maintain production RH below 45%. Solubility and flow are balanced by our 60-80 mesh size. Request flow-agent pre-blend for high-humidity environments.
Q: May I call this "Sugar-Free"?
A: Market-specific regulatory categorization. It may be "low glycemic" but is usually considered a carbohydrate in the U.S. We give market-specific advice with each order.
Q: What's the advantage over cranberry extract alone?
A: Mechanisms vary. Cranberry PACs degrade; D-Mannose is consistent and quantifiable. It also soothes sensitive tummies. Many brands use both for synergy.
Q: Shelf life and storage?
A: 24 months unopened. Store in cold, dry (<25°C) conditions. Reseal opened containers promptly.
Do you have more questions about D-Mannose 99%?
Email: info@em-herb.com